"What you can not create, you can not understand.", Richard Feynman

Highlights

    Published papers in multi-disciplinary research areas, which include optimization algorithms, biophysics, modeling of biological pathways, and synthetic biology.
    Possessed nine years of research experience in both computational and experimental biology.
    Collaborated effectively and productively with cancer biologist, biochemist, engineers, and statisticians.

Peer Reviewed

(Cumulative cites: 266)
  1. C. Tan, R. Smith, and L. You. Inoculum effect, bistability, and the efficacy of periodic antibiotic treatment. Nature, 1st round review.

  2. R. Smith, H. Song, C. Tan, H. Song, and L. You. Allee effect resolves the dispersion paradox of invasive species. In preparation.

  3. G. Yao, C. Tan, J. R. Nevins, and L. You. Essential regulatory features underlying the Rb-E2F switch that controls mammalian cell cycle entry. 2nd round revision, Molecular Systems Biology.

  4. M. Hallen, Y. Tanouchi, C. Tan, L. You. Direct calculation of steady-state molecule number probability distributions in biochemical networks subject to intrinsic and extrinsic noise. PLoS Comp. Bio, 1st round review

  5. C. Tan and L. You. Decoding phenotypic signatures in dynamics of unbalanced bacterial growth. In preparation.

  6. C. Tan, P. Marguet, and L. You. Emergent bistability by a growth-modulating positive feedback circuit. Nature Chemical Biology, 2010. pdf

  7. Q. Wang, J. Niemi, C. Tan , L. You and M. West. Image segmentation and dynamic lineage analysis in single-cell fluorescent microscopy. Cytometry A, 2010. pdf

  8. C. Tan, F. Reza, and L. You. Noise-limited frequency signal transmission in gene circuits. Biophysical Journal, 2007. pdf

  9. C. Tan, H. Song, J. Niemi, and L. You. A synthetic biology challenge: making cells compute. Molecular BioSystems, 2007. pdf

  10. P. Marguet, F. Balagadde, C. Tan, and L. You. Biology by design: reduction and synthesis of cellular components and behaviour. J. Royal Society Interface, 2007. pdf

  11. K.-H. Chiam*, C. Tan*, V. Bhargava, and G. Rajagopal. Hybrid simulations of stochastic reaction-diffusion processes for modeling intracellular signaling pathways. Physical Review E, 2006 (*Equal contribution). pdf

  12. P. Dhar, C. Tan, S. Somani, Y. Li, K. Sakharkar, A. Krishnan, A. Ridwan, M. Chitre, and H. Zhu. Grid Cellware: The first Grid-enabled tool for modeling and simulating cellular processes. Bioinformatics, 2005, Vol 21, Number 7, pp 1284-1287. pdf

  13. C. Tan, S. Somani, and P. Dhar. Modeling and simulation of biological systems with stochasticity. In-Silico Biology, 4, 0024, 2004. pdf

  14. P. Dhar, C. Tan, S. Somani, Y. Li, A. Sairam, M. Chitre , H. Zhu, and K. Sakharkar. Cellware: a multi-algorithmic software for computational systems biology. Bioinformatics, 2004, Vol 20, Number 8, pp 1319-1321. pdf

Conference Papers

  1. T. Ray, H. Tsai, and C. Tan. Effects of Solver Fidelity on a Parallel Search Algorithm's Performance for Airfoil Shape Optimization Problems. 9th AIAA/ISSMO Symposium on Multidisciplinary Analysis and Optimization Conference, 2002, Atlanta, Georgia. pdf

  2. C. Tan, T. Ray, and H. Tsai.Effects of Adaptive Search Space Operator on Performance of SWARM Algorithm for Airfoil Design Optimization. 41st Aerospace Sciences Meeting and Exhibit, 2003, Reno, Nevada.

  3. C. Tan, T. Ray, and H. Tsai. A Comparative Analysis of Evolutionary Algorithm and Swarm Algorithm for Airfoil Design Problems. 41st Aerospace Sciences Meeting and Exhibit, 2003, Reno, Nevada.

Book Chapters

  1. H. Song, S. Payne, C. Tan, and L. You. Engineering bacterial cell-cell communication. N. Bergman (Editor). Wiley-Blackwell. Submitted, 2008.

  2. T. Lee, C. Tan, D. Tu, and L. You. Modeling cellular networks. In Bioinformatics: An Engineering Case-Based Approach, Eds. G. Alterovitz & M. Ramoni. In press, 2007

Presentation

  1. Growth modulation turns a noncooperative positive feedback bistable. Institute of Biological Engineering Annual Meeting, Chapel Hill, 2008.

  2. Bistability in an integrated protein and gene regulatory network. Biomedical Engineering Society Annual Fall Meeting 2006, Chicago