Bill Barry's academic page



Contact information:

William T. Barry, Ph.D.
Assistant Professor
Department of Biostatistics and Bioinformatics
Institute for Genome Science and Policy

Office address
Hock Plaza, Suite 1102, Rm 11086
2424 Erwin Rd
Durham, NC 27705
Phone:  (919) 681-5047
Fax:    (919) 668-9335
E-mail:   bill <DOT> barry <AT> duke <DOT> edu

Mailing address
DUMC Box 2721
Durham, NC 27710



Selected Topics/publications:

Workshops and Invited Lectures
  1. Society for Clinical Trials Annual Meeting, 2011: Development of multiplex biomarkers: Statistical considerations with high dimensional data. Herbert Pang and William Barry Slides and R code

  2. EORTC-NCI-ASCO Annual Meeting, 2011: A genomic-based signature of response to chemotherapy in ovarian cancer fails to predict clinical outcome in two independent cohorts W. Barry, W. Chen, G. Sfakianos, P. Isner, M. Datto, N. Kuderer, G. Lyman, A. Abernethy, G. Ginsburg, A. Berchuck Slides and Supplemental material

Microarrays: Pre-processing and QC
  1. Owzar K, Barry WT, Jung S, Sohn I, George SL (2008) Statistical Challenges in Pre-Processing in Microarray Experiments in Cancer. Clinical Cancer Research 14:5959-5966

  2. Bioconductor packages: affy, simpleaffy, affyPLM

Microarrays: Pathway analysis ( SAFE )
  1. Barry WT, Nobel AB, Wright FA. (2005) Significance analysis of functional categories in gene expression studies: a structured permutation approach. Bioinformatics 21(9):1943-9. Supplementary material & software.

  2. Barry WT, Nobel AB, Wright FA. (2008) A statistical framework for testing functional categories in microarray data. Annals of Applied Statistics 2(1):286-315. Software.
  3. Bioconductor packages: safe, GOstats, globaltest

Microarrays: Predictive/prognostic signatures in cancer
  1. Publications

    Barry WT, Kernagis DN, Dressman HK, Griffis RJ, Hunter J, Marcom K, Nevins JR, Geradts J, Datto MB (2010) Intra-tumor Heterogeneity Does Not Preclude Precise Microarray-Based Prediction of Breast Cancer Biology Journal of Clinical Oncology, 28(13):2198-206.

    Mendiratta P, Mostaghel E, Guinney J, Tewari A, Porrello A, Barry WT, Nelson P, Febbo PG (2009) A Genomic Strategy for Targeting Therapy in Castration-Resistant Prostate Cancer Journal of Clinical Oncology, 27(12):2022-9.

    Friedman DR, Weinberg JB, Barry WT, Goodman BK, Volkheimer AD, Bond KM, Chen Y, Jiang N, Moore JO, Gockerman JP, Diehl LF, Decastro CM, Potti A, Nevins JR (2009) A Genomic Approach to Improve Prognosis and Predict Therapeutic Response in Chronic Lymphocytic Leukemia Clinical Cancer Research, 15(22):6947-55.

    Gatza ML, Lucas JE, Barry WT, Kim JW, Wang Q, Crawford MD, Datto MB, Kelley M, Mathey-Prevot B, Potti A, Nevins JR (2010) A pathway-based classification of human breast cancer Proceedings of the National Academy of Sciences USA, 107(15):6994-9.


  2. Software packages:
    BinReg (Binary Probit Regression with SVD)
    BinTree (Binary Tree Prediction Model)