BME 207: Transport Phenomena in Biological Systems
References
1. "Fundamentals of Momentum, Heat, and Mass Transfer" By
J.E. Welty, C.E. Wicks, and R.E. Wilson
2."Basic Transport Phenomena in Biomedical Engineering" By
Ronald L. Fournier
3. "Transport Phenomena" By
R. Byron Bird, Warren E. Stewart, and Edwin N. Lightfoot
4. "Analysis of Transport Phenomena" By William M. Deen
5. Handouts
Topics
A. Elements of Fluid Mechanics
Momentum, mass, and energy balances: control volume approach
Fluid rheology
Dimensional analysis and scaling
Low Reynolds number flow
Boundary layer theory
Flow in porous media
Special topic: Rheology of blood
Special topic: Locomotion at low Reynolds numbers
B. Fundamentals of Mass Transport
Introduction to diffusion concepts
Conservation of mass
Convection / diffusion equation
Membrane transport
Special topic: Oxygen transport
Special topic: Electrolyte transport
C. Applications of Differential Transport Equations
Steady diffusion without reaction
Unsteady diffusion
Diffusion with reaction
Special topic: Controlled drug release
Special topic: Pharmacokinetic analysis
D. Computer projects and term papers
BME 265: Advanced Topics in Drug Delivery
Introduction to drug delivery in solid tumors and normal organs
(e.g., reproductive organs, kidney, skin, eyes). The course will
emphasize quantitative analysis of drug transport. Specific topics
include: physiologically-based pharmacokinetic analysis,
microcirculation, network analysis of oxygen transport, transvascular
transport, interstitial transport, transport across cell membrane,
specific issues in the delivery of cells and genes, drug delivery
systems, and targeted drug delivery. Prerequisite: BME 207.