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James's Curriculum Vitae

Download my CV in PDF format here soon.

Education

• Ph.D. Candidate Duke University, Durham, NC                  Aug, 2005 to present
  Department of Chemistry and Center for Biomolecular and Tissue Engineering
  Chemistry, Specialization Bio-inorganic
  Advisor: A. L. Crumbliss.
• B.S. University of North Carolina at Wilmington                  Aug, 2000 to Dec, 2004
  Department of Chemistry and Biochemistry
  Chemistry, emphasis in Inorganic, minor Philosophy
  Advisors: R. D. Hancock and S. B. Jones

Awards and Honors

• 2008               Pelham Wilder Teaching Award, Duke
• 2008               Preparing Future Faculty Fellow, Duke
• 2006-pres      Predoctoral NIH Traineeship, Center for Biomolecular and Tissue Engineering, Duke
• 2004               University and Departmental Honors, UNCW
• 2004               Magna Cum Laude, UNCW
• 2004               Chancellor’s List, UNCW
• 2004               Phi Kappa Phi inductee, UNCW
• 2004               Gamma Sigma Epsilon inductee, UNCW
• 2003               Chancellor’s List, UNCW
• 2003               DeLoach Award for Outstanding Students in Organic Chemistry
• 2002               Phi Eta Sigma inductee, UNCW
• 2002               Chancellor’s List, UNCW
• 2001               Chancellor’s List, UNCW

Research Techniques

• Inorganic:        UV-Vis Spectroscopy, Differential Pulse Voltammetry, Crystal Synthesis, HPLC purification, Ligand Synthesis, Potentiometry, Infrared Spectroscopy, NMR spectroscopy, Computational Molecular Modeling, Cyclic Voltammetry, Stop-flow spectrophotometry, Mass spectral analysis
  
• Biological:       Sample Preparation, gel preparation, protein preparation, care of test subjects, toxicity assays in C. elegans

Employment

• National Institute of Environmental Health and Safety
  Research Assistant                    Jul 2009 to Sept 2009
  Responsibilities: Design assays of metal toxicity in C. elegans
• Duke Chemistry Department
  Teaching assistant                   Sept, 2005 to Aug, 2006
  Courses taught: Accelerated General Chemistry, General Chemistry I and II
  
• UNCW Chemistry Department
  Research assistant                 Jan, 2003 to Aug, 2005
  Reponsibilities: Design and perform chemical experiments for research purposes
  
• UNCW Center for Marine Science
  Lab technician                 Jan, 2002 to Jun, 2002
  Responsibilities: Prepare biological samples for use in experiments

Mentoring Experience

• 2 undergraduate: inorganic synthesis and analytical chemistry

Volunteer Experience

• Chemical Demonstrator
  Duke University                 Sept 2005 to present
  Responsibilities: Learn, perform, and teach chemical demonstrations for the Chemical Demonstration Team at Duke University (see Activities page)
• Co-organizer, Chalk Talk lecture series
  Duke University                                                          AY2008-09
  Responsibilities: Contact and arrange speakers on a range of topics pertaining to job searches and life after academia

Publications

• Harrington, James M., The Possible Role of Relativistic Effects in the Formation of Cadmium Complexes with Crown Ethers, (2004) Honors Thesis, University of North Carolina at Wilmington.  Advisors Robert D. Hancock and S. Bart Jones.
  
  
• Harrington, James M., Dhungana, Suraj, Chittamuru, Sumathi, Jacobs, Hollie K., Gopalan, Aravamudan S., and Crumbliss, Alvin L., Iron Sequestration Equilibria for Some New Tetradentate and Hexadentate 3-Hydroxy-2-pyridinone Donor Group Siderophore Mimics, (2009), in preparation.
  
  
• Harrington, James M., Park, Heekwang, Ying, Yongcheng, Hong, Jiyong, Crumbliss, Alvin L., Thermodynamic Characterization of Iron(III) Binding by the Cytotoxic Siderophore, Brasilibactin A, (2009), in preparation.
  
  
• Harrington, James M., Crumbliss, Alvin L., Iron(III) Chelation by a Trojan Horse Antimicrobial Agent, PF-02538084: A Thermodynamic Study, (2009), in preparation.
  
  
• Harrington, James M., Crumbliss, Alvin L., The Redox Hypothesis in Siderophore-Mediated Iron Uptake, Biometals (2009), 22, 679-689.
  
  
• Crumbliss, Alvin L., Harrington, James M., Iron Sequestration by Small Molecules: Thermodynamic and Kinetic Studies of Natural Siderophores and Synthetic Model Compounds, in Advances in Inorganic Chemistry (2009), 61, 179-250.
  
  
• Harrington, James M., Jones, S. Bart, VanDerveer, Donald J., Bartolotti, Libero J., Hancock, Robert D, Structural, molecular mechanics, and DFT study of cadmium(II) in its crown ether complexes with axially coordinated ligands, and of the binding of thiocyanate to cadmium(II), Inorganica Chimica Acta (2009), 362(4), 1122-8.
  
  
• Dhungana, Suraj, Harrington, James M., Gebhardt, Peter,  Möllmann, Utë, and Crumbliss, Alvin L., Iron Chelation Equilibria, Redox, and Siderophore Activity of a Saccharide Platform Ferrichrome Analogue, Inorganic Chemistry (2007), 46(20), 8362-71.
  
  
• Harrington, James M., Oscarson, Karen, A., Jones, S. Bart, Reibenspies, Joseph H., Bartolotti, Libero J., Hancock, Robert D., The Affinity of Indium (III) for Nitrogen-Donor Ligands in Aqueous Solution.  A Study of the Complexing of Indium (III) with Polyamines by Differential Pulse Voltammetry, Density Functional Theory, and Crystallography.  Zeitschrift für Naturforschung B (2007), 62, 1-11.
  
  
• Hancock, Robert D.; Melton, Darren L.; Harrington, James M.; McDonald, F. Crisp; Gephart, Raymond T.; Boone, Lindsay L.; Jones, S. Bart; Dean, Nolan E.; Whitehead, Jason R.; Cockrell, Gregory M.  Metal ion recognition in aqueous solution by highly preorganized non-macrocyclic ligands.    Coordination Chemistry Reviews  (2007),  251(13+14),  1678-1689.
  
  
• Harrington, James M.; Jones, S. Bart; Hancock, Robert D., Determination of formation constants for complexes of very high stability: log b 4 for the [Pd(CN)4]2- ion. Inorganica Chimica Acta (2005), 358(15), 4473-4480.
  
  
• Harrington, James M.; Jones, S. Bart; White, Peter H.; Hancock, Robert D., Possible Role of Relativistic Effects in the Plasticity of the Coordination Geometry of Cadmium(II). A Voltammetric Study of the Stability of the Complexes of Cadmium(II) with 12-Crown-4, 15-Crown-5 and 18-Crown-6 in Aqueous Solution and the Structures of [Cd(benzo-18-crown-6)(NCS)2] and [K(18-crown-6)][Cd(SCN)3]. Inorganic Chemistry (2004), 43(14), 4456-4463.
  
  

Presentations and posters (presenter underlined)

• Harrington, James M., Chittamuru, Sumathi, Jacobs, Hollie K., Gopalan, Aravamudan S., and Crumbliss, Alvin L., Kinetics and mechanism of iron exchange between synthetic hydroxypyridinone chelators and molecules of biological interest. 238th National Meeting of the American Chemical Society, Washington, DC, United States, Aug. 17 (2009).
  
  
• Harrington, James M., Ying, Yongcheng, Park, Heekwang, Hong, Jiyong, and Crumbliss, Alvin L., Thermodynamic characterization of iron(III) and zinc binding by Brasilibactin A. (Poster) 238th National Meeting of the American Chemical Society, Washington, DC, United States, Aug. 17 (2009).
  
  
• Harrington, James M., Bioinorganic chemistry in teaching and research: Coordination chemistry of transition metals. (Poster) 238th National Meeting of the American Chemical Society, Washington, DC, United States, Aug. 17 (2009).
  
  
• Harrington, James M., Dhungana, Suraj, Chittamuru, Sumathi, Jacobs, Hollie K., Gopalan, Aravamudan S., and Crumbliss, Alvin L., Iron(III) sequestration by synthetic hydroxypyridinone siderophores and exchange with desferrioxamine B. 2nd Annual Chemical Sciences Symposium, NCA&T State University, Greensboro, NC, United States, Feb. 28 (2008).
• Harrington, James M., Dhungana, Suraj, Chittamuru, S., Jacobs, Hollie K., Gopalan, A. S., Crumbliss, Alvin L., Iron(III) sequestration by synthetic hydroxypyridinone siderophores and exchange with desferrioxamine B. 234th National Meeting of the American Chemical Society, Boston, MA, United States, Aug. 19-23 (2007).
  
  
• Harrington, James M., Dhungana, Suraj, Crumbliss, Alvin L., Binding of synthetic hydroxypyridinone Siderophores to iron in aqueous solution and exchange mechanism with the iron-desferrioxamine B complex. 121st Local Meeting of the North Carolina American Chemical Society, Durham, NC, United States, Apr. 21 (2007).
  
  
• Harrington, James M.; Jones, S. Bart; Hancock, Robert D., Investigation of Relativistic effects in the formation of cadmium complexes. (Poster) 56th Southeast Regional Meeting of the American Chemical Society, Research Triangle Park, NC, United States, November 10-13 (2004).
  
  
• Jones, S.; Harrington, James; Hancock, Robert. Stability of complexes of lead and cadmium with crown ethers, and the role of relativistic effects in the chemistry of group 12 ions>.  (Poster) 55th Southeast Regional Meeting of the American Chemical Society, Atlanta, GA, United States, November 16-19, 2003 (2003).
  
  

References

• Dr. Alvin L. Crumbliss
  Dean of Natural Sciences
  Bishop-MacDermott Family Professor of Chemistry
  Room 2104 French Family Science
  Box 90346 Duke University
  Durham, NC 27708-0346
  919-660-1540
  
  
• Dr. Robert D. Hancock
  Will S. DeLoach Distinguished Professor of Chemistry
  Room 234 Dobo Hall
  University of North Carolina at Wilmington
  Wilmington, NC 28403
  910-962-3025
  
  
• Dr. S. Bart Jones
  Associate Professor of Chemistry
  Room 236 Dobo Hall
  University of North Carolina at Wilmington
  Wilmington, NC 28403
  910-962-3211
  
  
• Dr. Kenneth Lyle
  Instructor
  Room 1232 French Family
  Duke University
  Durham, NC 27708
  919-660-1621