Wiley Schell, Associate Professor

Associate Professor in Medicine Department of Medicine
Division of Infectious Diseases and International Health
Duke University Medical Center

Director
Medical Mycology Research Center

1552 Stead Building
Box 3303 DUMC
Durham, N.C. 27710
Phone: (919) 684-2523
Fax: (919) 684-8902
Email: wiley.schell@duke.edu

M.S. Department of Botany, 1979
The University of North Carolina at Chapel Hill

Lab members:	telephone: 919.668.6368
Nancy Myers, BS, MT
Arthur Lee, undergraduate	arthur.lee@duke.edu

Interests

Editorial Board, Revista Iberoamericana de Micologia. English Language Assistance Editor, 2007- present.

Clinical and Laboratory Standards Institute, Subcommittee on Principles and Procedures for Fungal Cultures, Advisor, 2009-present.

Molecular Mycology and Pathogenesis Training Program. Duke University Medical Center. Faculty, 2003- present.

Duke Center for AIDS Research, Program in Opportunistic Infections. Member, 2005- present.

Public Health Preparedness Database, State of North Carolina Department of Health and Human Services. Content Expert, 2005- present.

Laboratory Quality Assurance Program. American Industrial Hygiene Association, Fairfax, Viriginia. Site Assessor, 2007-present.

Environmental Microbiology Laboratory Accreditation Program (EMLAP), and Environmental Microbiology Proficiency Analytical Testing program (EMPAT). American Industrial Hygiene Association, Fairfax, Virginia. Pre-Evaluator for fungus challenges, 2005- present.

Analytical Accreditation Board Task Force on the Environmental Microbiology Laboratory Accreditation Program (EMLAP). American Industrial Hygiene Association, Fairfax, Virginia. Member, 2003- present.

ASTM International, subcommittee on Sampling and Analysis of Mold, Member, 2006- present.

Standard Methods Committee, Standard Methods for the Examination of Water and Waste Water. Member, 2006- present.

Faculty of 1000 Biology. Microbiology, section Medical Microbiology. Member, 2005-2010.

International Studies of Aids-Associated Co-Infections, Duke University Medical Center and Kilimanjaro Christian Medical Center, Moshi, Tanzania. Investigator, 2004- 2009.

Analytical Accreditation Board Task Force on Environmental Microbiology Proficiency Analytical Testing program (EMPAT). American Industrial Hygiene Association, Fairfax, Virginia. Member, 2003- 2009.

Council, The Medical Mycological Society of the Americas, Counselor East, 2006-2009.

Awards Committee, American Biological Safety Association, Mundelein, Illinois. Member, 2005-2008.

All Taxa Biodiversity Inventory (ATBI) of Great Smoky Mountains National Park. Project Volunteer, Mycology, 1999-2007.

Billy H. Cooper Award, for outstanding contributions to the practice of diagnostic clinical mycology, The Medical Mycological Society of the Americas, 2006.

Espinel-Ingroff A, canton E, Ghannoum M, Johnson L, Jones R, Ostrosky-Zeichner L, Schell WA, Gibbs, DL, Wang A, Turnidge J. Quality control limits for amphotericin B, itraconazole, posaconazole and voriconazole disk susceptibility tests on non-supplemented Mueller-Hinton agar (CLSI M51-A document) of non-dermatophyte filamentous fungi. Submitted.

Pfeiffer CD, Samsa GP, Schell WA, Reller LB, Perfect JR, Alexander BD. Quantitation of Candida colony forming units in initial positive blood cultures. Submitted.

Schell WA, Lee AG, Aimee MC. A new lineage in Pucciniomycotina: class Tritirachiomycetes, order Tritirachiales, family Tritirachiaceae. Mycologia, 2011.

Schell WA, O'Donnell K, Alspaugh A. Heterothallic Mating in Mucor irregularis and First Isolate of the Species Outside of Asia. Medical Mycology, 2011.

LaFayette SL, Collins C, Zaas AK, Schell WA, Betancourt-Quiroz M, Gunatilaka L, Perfect JR, Cowen LE. PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90. PLoS Pathog 6 (8) e 101069; 2010.

Alexander BD, Schell WA, Park BJ et al. Fatal Apophysomyces elegans infection transmitted by deceased donor renal grafts. Am J Transplant 10: 2161-7; 2010.

Wulff-Burchfield E, Schell WA, Eckhart AE et al. Microfluidic Platform versus Conventional Real-time PCR for the Detection of Mycoplasma pneumoniae in Respiratory Specimens. Diag. Microbiol. Infect. Dis. 67: 22-29; 2010.

Perfect JR, Alexander BD, Schell WA. Phaeohyphomycoses. Essentials of Clinical Mycology 2nd edition, Ed. Kauffamn, Sobel, Pappas, Dismukes. In press.

Hua Z, Rouse JL, Eckhardt AE, Srinivasan V, Pamula VK, Schell WA, Benton JL, Mitchell TG, Pollack MG. Multiplexed real-time polymerase chain reaction on a digital microfluidic platform. Anal. Chem. 82: 2010.

Singh SD, Robbins N, Zaas AK, Schell WA, Perfect JA, Cowen LE. Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin. PLoS Pathog. 5 (7), e1000532; 2009.

Cowen LE, Singh SD, Kohler JR, Collins C, Zaas AK, Schell WA, Aziz H, Mylonakis E, Perfect JR, Whitesell L, Lindquist S. Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. Proc. Natl. Acad. Sci. USA. Feb 24;106(8):2818-23. Epub 2009 Feb 5, 2009.

Schell WA, Foulks GN, Perfect JR. Fungal Infections of the Eye. In: Principles and Practice of Ophthalmology, 3rd edition. W.B. Saunders Co., Philadelphia; 2008.

Onyewu C, Eads E, Schell WA, Perfect J, Ullmann Y, Kaufman G, Horwitz BA, Berdicevsky I, Heitman J. Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model. Antimicrob. Agents Chemother. 51:3743-6; 2007.

Espinel-Ingroff A, Fothergill A, Ghannoum M, Manavagthu E, Ostrosky-Zeichner L, Pfaller M, Rinaldi M, Schell WA, Walsh TJ. Quality control and Reference Guidelines for CLSI Broth Microdilution Method (M38-A Document) for Susceptibility Testing of Anidulafungin against Molds. J. Clin. Microbiol. 45: 2180-2182; 2007.

Smith PB, Steinbach WJ, Cotton M, Schell WA, Perfect JR, Walsh TJ, Benjamin Jr. DK. Successful use of caspofungin in the treatment of azole resistant candidemia in a premature infant. J. Perinatol.27:127-129; 2007.

Guarro J, Severo LC, Gene J, Mattos Oliveira F de, Cano JF, Franche Guilherme, Canterelli VV, Schell WA. Sinusitis by the fungus Xylaria enteroleuca in a lung transplant patient. Diag. Microbiol. Infect. Dis. 56:207-212; 2006.

Alexander BD, Schell WA. Hyalohyphomycosis. In: Atlas of Infectious Diseases; Fungal Infections; pp 253-266. Current Medicine, Philadelphia; 2006

Schell WA. Mycotic Agents of Human Disease. In: Hunt DL, Fleming DO, ed. Biological Safety : Principles and Practices, 4th edition, pp163-178. ASM Press, Washington, D.C. 2006.

Alexander BD, Schell WA, Miller JL, Long GD, Perfect JR. Candida glabrata fungemia in patients receiving voriconazole after fluconazole. Transplantation 80:868-871; 2005.

Espinel-Ingroff, Fothergill A, Ghannoum M, Manavathu E, Ostrosky-Zeichner L, Pfaller M, Rinaldi M, Schell W, Walsh T. Quality control and reference guidelines for CLSI broth microdilution susceptibility method (M38 document) for amphotericin B, itraconazole, posaconazole, and voriconazole. J. Clin. Microbiol. 43:5243-5246; 2005.

Schell WA, Esterre P. Chromoblastomycosis. In: Collier L, ed. Topley & Wilson’s Microbiology and Microbial Infections, 10th edition, pp 356-366. Edward Arnold, Ltd., London; 2005.

Chang CY, Schell WA, Perfect JR, Hulka GF. Novel use of a swimming pool biocide in the treatment of a rare fungal mastoiditis (Lecythophora hoffmannii). Laryngoscope 115:1065-69; 2005.

Steinbach WJ, Schell WA, Miller JL, Martin PL, Perfect JR. Scopulariopsis brevicaulis infection in a stem-cell transplant patient treated with voriconazole and caspofungin and a review of Scopulariopsis infections in immunocompromised patients. J. Infect. 48:112-116; 2004.

Miller J, Schell WA, Wills EA, Toffaletti DL, Boyce M, Benjamin, Jr. DK, Bartroli J, Perfect JR. In vitro and in vivo efficacy of the new triazole albaconazole (UR-9825) against Cryptococcus neoformans. Antimicrob. Agents Chemother. 48:384-387; 2004.

Steinbach WJ, Schell WA, Blankenship JR, Onyewu C, Heitman J, Perfect JR. In vitro interactions between the immunosuppressive drugs FK 506 and cyclosporin A with caspofungin against Aspergillus fumigatus. Antimicrob. Agents Chemother., 48:1664-1669; 2004.

Taj-Aldeen SJ, Hillal AA, Schell WA. Allergic fungal rhinosinusitis: a report of eight cases. Am. J. Otolaryngol. 25:213-218; 2004.

Steinbach WJ, Walsh TJ, Schell WA, Perfect JR, Benjamin Jr. DK. Review of in vitro analyses, animal models, and 60 clinical cases of invasive Aspergillus terreus infection. Antimicrob. Agents Chemother. 48:3217-3225; 2004.

Odds, FC, Motyl M, Andrade R, Bille J, Canton E, Cuenca-Estrella M, Davidson A, Durussel C, Ellis D, Foraker E, Fothergill AW, Ghannoum MA, Giacobbe RA, Gobernado M, Handke R, Laverdiere M, Lee-Yang W, Merz WG, Ostrosky-Zeichner L, Peman J, Perea S, Perfect JR, Pfaller MA, Proia L, Rex JH, Rinaldi MG, Rodriguez-Tuleda J, Schell WA, Shields C, Sutton DA, Verweij PE. Warnock DW. Interlaboratory comparison of results of susceptibility testing with caspofungin against Candida and Aspergillus species: an interlaboratory comparison. J. Clin. Microbiol.,42:3475-3482; 2004.

Miwa T, Takagi Y, Shinozaki M, Yun C, Schell WA, Perfect JR, Kumagai H, Tamaki H. Gpr1, a putative G-protein coupled receptor, regulates morphogenesis and hyphal formation in the pathogenesis of the fungus Candida albicans. Euk. Cell. 3:919-931; 2004.

Jiménez-Expósito MJ, Torres G, Baraldés A, Benito N, Marco F, Paré JC, Moreno A, Claramonte X, Mestres CA, Almela M, García de la María C, Pérez N, Schell WA, Corey GR, Perfect J, Jiménez de Anta MT, Gatell JM, Miró JM. Native valve endocarditis due to Candida glabrata treated without valvular replacement: role of caspofungin in the induction and maintenance treatment. Clin. Infect. Dis. 39: e70-73; 2004.

Steinbach WJ, Benjamin DK, Trasi SA, Miller JL, Schell WA, Zaas AK, Foster WM, Perfect JR. Value of an inhalational model of invasive aspergillosis. Medical Mycology 42:417-25; 2004.

Schell WA. Dematiaceous Hyphomycetes. In: Howard DH, ed. Fungi Pathogenic for Humans and Animals: Second Edition, Revised and Expanded, pp565-636. Marcel Dekker, Inc., New York. 2003.

Blankenship JR, Wormley FL, Boyce MK, Schell WA, Filler SG, Perfect JR, Heitman J. Calcineurin is essential for Candida albicans survival in serum and virulence. Eukaryotic Cell 2: 422-430; 2003

Schell WA, Salkin IF, McGinnins MR. Bipolaris, Exophiala, Scedosporium, Sporothrix and other dematiaceous fungi. In: Murray PR, Baron EJ, Jorgensen JH, Pfaller MA, Yolken RH, eds. Manual of Clinical Microbiology, 8th Ed., pp 1820-1847. American Society for Microbiology, Washington D.C. 2003.

Gottfredsson M, Vredenburgh JJ, Xu J, Schell WA, Perfect JR. Candidemia in women treated with high dose chemotherapy and autologous bone marrow transplantation for metastatic breast cancer. Cancer, 98:24-30; 2003.

Walsh TJ, Larone DH, Schell WA, Mitchell TG. Histoplasma, Blastomyces, Coccidioides, and Other Dimorphic Fungi Causing Systemic Mycoses. In: Murray PR, Baron EJ, Jorgensen JH, Pfaller MA, Yolken RH Murray PR, eds. Manual of Clinical Microbiology, 8th Ed., pp 1781-1797. American Society for Microbiology, Washington D.C. 2003.

Trinh JV, Steinbach WJ, Schell WA, Kurtzberg J, Giles S, Perfect JR. Cerebral phaeohyphomycosis in an immunodeficient child treated medically with combination antifungal therapy. Medical Mycol. 41:339-345; 2003.

Perfect JR, Schell WA, Cox GM. Phaeohyphomycosis. Clinical Mycology, ed. Dismukes, Pappas, Sobel. Oxford University Press. 271-282; 2003.

Steinbach WJ, Schell WA, Miller JL, Perfect JR. Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole, caspofungin and local polyhexamtheylene biguanide (PHMB). J. Clin. Microbiol. 41:3981-3985; 2003.

Zaas AK, Boyce M, Schell WA, Miller JL, Alexander-Lodge B, Perfect JR. Rhodotorula fungemia: risks and Antifungal susceptibility. J. Clin. Microbiol. 41:5233-5235; 2003.

Steinbach WJ, Mitchell TG, Schell WA, Espinel-Ingroff A, Coico RF, Walsh TJ, Perfect JR Current Status of Medical Mycology Education. Medical Mycology, 41:457-467; 2003.

Engemann J, Kaye K, Cox G, Perfect J, Schell W et al. Exophiala infection from contaminated injectable steroids prepared by a compounding pharmacy--United States, July--November 2002. MMWR 51(49);1109-1112.

Risk Analyses and Reports on the Operation of the Boston University Medical Center National Emerging Infectious Diseases Laboratories. TetraTech, Inc. In preparation.

Environmental Impact Statement for the Transport of Laboratory Personnel Exposed to Infectious Agents from Fort Detrick, Frederick, Maryland to the National Institutes of Health Clinical Center, Bethesda, Maryland. Tetra Tech, Inc. In preparation.

Environmental Assessment for the Pacific Regional Biosafety Laboratory at The University of Hawaii at Manoa, Oahu, Hawaii. Tetra Tech, Inc. In preparation.

Environmental Impact Statement for the Operation of a Biosafety Level 3 Facility at Los Alamos National Laboratory, Los Alamos, New Mexico. Tetra Tech, Inc. In preparation.

Environmental Impact Statement for the National Bio and Agro-Defense Facility (NBAF). Tetra Tech, Inc. November, 2008.

Environmental Impact Statement for the Galveston National Laboratory for Biodefense and Emerging Infectious Diseases Research Facility in Galveston, Texas. Tetra Tech, Inc. February, 2005.

Environmental Assessment for Tests and Experiments Using Biological Materials and Releases of Chemicals Including Modifications of Release Parameters for the Hazardous Materials Spill Center at the Nevada Test Site. Tetra Tech, Inc. May, 2004.

The Body and Disease. School of Medicine, Duke University, Faculty, 2005-present.

Medical Mycology (MIC 324B). Department of Molecular Genetics and Microbiology, Duke University. Faculty, 1985-present.

Medical Mycology. Division of Dermatology, Duke Medical Center. Faculty Instructor, 1985-present.

Medical Microbiology (MGM 200). School of Medicine, Department of Molecular Genetics and Microbiology, Duke University. Faculty Instructor, 1985-2004.

American Society for Microbiology
International Society for Human and Animal Mycology
Medical Mycological Society of the Americas
Mycology Society of America
International Society for Infectious Diseases
American Biological Safety Association
American Industrial Hygiene Association
ASTM International
Pan-American Aerobiology Association
International Association for Aerobiology