Publications (feel free to contact me for PDF preprints or reprints)
2009
o H. Song, S. Payne, M. Gray, and L. You (2009). Spatiotemporal modulation of biodiversity in a synthetic chemical-mediated ecosystem. Nature Chemical Biology. Published online. doi:10.1038/nchembio.244
o Q. Wang, J Niemi, C. Tan, L. You and M. West (2009), Image segmentation and dynamic lineage analysis in single-cell fluorescence microscopy. Cytometry A. Published online. DOI:10.1002/cyto.a.20812
o C. Tan, P. Marguet, and L. You (2009). Emergent bistability by a growth-modulating positive feedback circuit. Nature Chemical Biology. 5, 842 - 848. [News & Views: Slow growth leads to a switch]
o
A. Pai, Y. Tanouchi, C.
Collins, and L. You (2009). Engineering multicellular systems by cell-cell
communication. Current
Opinion in Biotechnology. 
DOI:10.1016/j.copbio.2009.08.006
o A. Pai and L. You (2009). Optimal tuning of bacterial sensing potential. Molecular Systems Biology. 2009; 5:286.
o Y. Tanouchi, A. Pai, and L. You (2009). Decoding biological design principles using gene circuits (2009). Molecular BioSystems. DOI: 10.1039/b901584c
o F. J. Isaacs, and L. You (2009). A brave new synthetic world . Genome Biology. 10:302
2008
o C. Smith, H. Song, and L. You (2008). Signal discrimination by differential regulation of protein stability in quorum sensing. J. Molecular Biology. 382(5):1290-7
o Y. Tanouchi, D. Tu, J. Kim, and L. You (2008). Noise reduction by diffusional dissipation in a minimal quorum sensing motif. PLoS Computational Biology.4(8): e1000167. doi:10.1371/journal.pcbi.1000167
o K. Brenner, L. You, and F. H. Arnold (2008). Engineering microbial consortia: a new frontier for synthetic biology. Trends in Biotechnology. 26: 483-489
o F. Balagadde, H. Song, J. Ozaki, C. Collins, M. Barnet, F. H. Arnold, S. Quake, and L. You (2008). A synthetic Escherichia coli predator-prey ecosystem. Molecular Systems Biology. 4:187. Faculty of 1000 Biology, Must Read.
o G. Yao, T. Lee, S. Mori, J. Nevins#, and L. You# (2008). A bistable Rb-E2F switch underlies the restriction point. Nature Cell Biology. Published online.Faculty of 1000 Biology, Must Read.
o T. Lee, G. Yao, J. Nevins, and L. You (2008). Sensing and integration of Erk and PI3K signals by Myc. PLoS Computational Biology. 4(2): e1000013. doi:10.1371/journal.pcbi.1000013
o J. V. Wong, H. Song, and L. You (2008). A whole more than the sum of its synthetic parts (Point of View). ACS Chemical Biology. 3(1):27-9.
2007
o C. Tan, F. Reza, and L. You (2007). Noise-limited frequency signal transmission in gene circuits. Biophysical J. 93(11):3753-61.
o C. Tan, H. Song, J. Niemi, and L. You (2007). A synthetic biology challenge: making cells compute. Molecular BioSystems. 3:343.
o Reza F, Chandran K, Feltz M, Heinz A, Josephs E, O’Brien P, Dyke B, Chung H, Indurkhya S, lakhani N, Lee J, Lin S, Tang N, LaBean T, You L, Yuan F, and Tian J (2007). Engineering novel synthetic biological systems, IET Synthetic Biology, vol. 1, pp. 48-52 .
o P. Marguet, F. Balagadde, C. Tan, and L. You (2007). Biology by design: reduction and synthesis of cellular components and behavior. J. Royal Society Interface.4:607
o D. Tu, J. Lee, T. Ozdere, T. Lee, and L. You (2007). Engineering gene circuits: foundations and applications. In Nanotechnology in Biology and Medicine Methods, Devices and Applications, Ed. T. Vo-Dinh. CRC Press. Chapter 21.
o T. Lee, C. M. Tan, D. Tu, and L. You (2007). Modeling cellular networks. In Bioinformatics: An Engineering Case-Based Approach, Eds. G. Alterovitz & M. Ramoni. Chapter 6.
2006
o H. Song and L. You (2006). Evolving Sensitivity (Point of View). ACS Chemical Biology. 1:681.
o L. You and J. Yin. (2006). Evolutionary design on a budget: robustness and optimality of bacteriophage T7. IEE. Systems Biology. 153:46-52.
2005
o F. K. Balagadde *, L. You*, C. Hansen, F. H. Arnold and S. Quake. (2005). Long-term monitoring of bacteria undergoing programmed population control in a microchemostat, Science. 309: 137-140 (* contributed equally). Faculty of 1000 Biology, Recommended.
2004 and before
o L. You, R. S. Cox III, R. Weiss, and F. H. Arnold. (2004). Programmed population control by cell-cell communication and regulated killing. Nature. 428: 868-871. Featured in ScienceNow (405:3).
o L. You, (2004) Towards computational systems biology. Cell Biochemistry and Biophysics. 40: 167-184
o L. You, A. Hoonlor, and J. Yin. (2003) Modeling biological systems using Dynetica: a simulator of dynamic networks. Bioinformatics. 19: 435-436. Click hereto see more
o L. You and J. Yin (2002). Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage T7. Genetics. 160: 1273-1281
o L. You, P. F. Suthers, and J. Yin (2002). Effects of E. coli physiology on growth of phage T7 in vivo and in silico. J. Bacteriology. 184: 1888-1894. (Highlighted inEditors Choice of Science (2002), 296: 219)
o R. Srivastava, L. You, J. Summers, and J. Yin (2002). Stochastic versus deterministic modeling of intracellular viral kinetics. J. Theor. Biol. 218: 309-321.
o L. You and J. Yin (2001). Simulating the growth of viruses. Proceedings of the Pacific Symposium on Biocomputing: 532-543.
o L. You and J. Yin (2000). Patterns of regulation from mRNA and protein time-series Metabolic Engineering. 2: 210-217.
o D. Endy, L. You, J. Yin, and I. J. Molineux (2000). Computation, prediction, and experimental tests of fitness for bacteriophage T7 mutants with permuted genomes. Proc. Nat. Acad. Sci. USA. 97: 5375-5380.
o L. You and J. Yin (1999). Amplification and spread of viruses in a growing plaque. J. Theor. Biol. 200(4): 365-373.
o L. You, Q. Liu, Y. Shi, C. X. Wang, M. Lahaye, and V. Tran (1997). The conformational study of b-D-GlcA-(1,4)-L-Rha in solution by NMR and molecular dynamics simulations. Chemical Physics. 224: 81-94.